Immune Responses to Viral Vectors Used in Gene Therapy

CASTROLowenstein, PedroHrsg.Ertl, HildegundHrsg.

Immune Responses to Viral Vectors Used in Gene Therapy

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Beschreibung

Can the creativeness of gene therapists overcome the evolutionary advantage of the immune system? Gene therapy as clinical pharmacology and treatment of disease: Quo vadis?- Introductory overview: How the immune responses to viruses informs the use of viral vectors in gene therapy.- Immune responses to adenoviral vectors in the brain.- Innate and adaptive immune responses to adenoviral vectors administered systemically: cellular and molecular mechanisms.- The immune responses to adenoviral vectors: the clinical experience.- Immune responses to AAV vectors in the CNS.- Immune responses to AAV: experimental approaches and clinical implications.- Immune control of HSV: implications for gene therapy.- Immune responses to HSV vectors: implications for clinical trials of brain tumors.- Immune responses to HSV1-derived amplicon vectors.- Control of immune responses to lentiviral vectors administered systemically.- Innate immune responses to retroviral vectors.- The genetics of the immune responses to viral vectors in gene therapy.- Induction of tolerance to gene therapy and therapeutic products.

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